Acquired bleeding disorders

Acquired bleeding disorders.

tial acquired bleeding disorder is common in clinical practice. The most common cause is anticoagulant therapy, including antiplatelet drugs. With increasing use of pharmacological thromboprophylaxis in both medical and surgical inpatients and increasing indications for long-term antithrombotic therapy, it is imperative to consider drug-induced bleeding during the initial evaluation of abnormal...

Platelet von Willebrand factor in inherited and acquired bleeding disorders.

The majority of plasma proteins involved in the mechanisms of hemostasis are loosely adsorbed on the platelet surface. A few of them, however, can also be measured in washed platelets, in which they are contained in the intracellular organelles called a granules. The main proteins involved in blood coagulation concentrated in platelets are von Willebrand factor (vWF), fibrinogen, and factor V. ...

Bleeding Disorders

Bleeding disorders are usually taken to mean coagulopathies with reduced clotting of the blood but also encompass disorders characterised by abnormal platelet function or blood vessel walls that result in increased bleeding. Bleeding disorders may result from faults at many different levels in the coagulation process. They can range from severe and life-threatening conditions, such as haemophil...

Bleeding Disorders: Hemorrhagic Diatheses

Before discussing these specific bleeding disorders, it is helpful to review normal hemostasis ( Chapter 4 ) and the common laboratory tests used in the evaluation of a bleeding diathesis. It should be recalled from the discussion in Chapter 4 that the normal hemostatic response involves the blood vessel wall, the platelets, and the clotting cascade. Tests used to evaluate different aspects of ...

Bleeding Disorders in Animals